The science curriculum follows the framework of the Next Generation Science Standards using Discovery Education's ScienceX program. Students throughout all grade levels experience this holistic, applications-based approach connected to the school, the community, and the world. At the primary and elementary levels, Saint Anne Parish School develops innovative, self-reliant, logical thinkers who use a pre-engineering mindset to solve problems. Intermediate and middle school students are then able to use those engineering skills to design, test, and evaluate when performing applications in year-long nutrition studies, year-long sustainability studies, and through participation in local, regional, and state science fair competitions. These real-world units, which include Discovery Education STEM Connect and Coding, Discovery Education experiences, visits to Chicago museums, and studies in robotics, allow STEAM-based classrooms to extend beyond the walls of the science lab as teachers collaborate to develop the four disciplines of science, technology, engineering, and math as well as make connections to English Language Arts and the social sciences.